منابع مشابه
Differential labelling of intraneuronal noradrenaline stores with different concentrations of (-)-3H-noradrenaline.
Isolated preparations of the rabbit vas deferens were incubated with (--)-(3)H-nor- adrenaline. A preferential release of (3)H-noradrenaline was demonstrated after electrical stimulation of the intramural nerves in those tissues labelled with 10 ng/ml (3)H-noradrenaline. There was no preferential release of (3)H-noradrenaline when the vasa were initially labelled with 100 ng/ml (3)H-noradrenali...
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Although the underlying basis for the defective myocardial function characteristic of congestive heart failure has not been defined, the contractile state of the myocardium is known to be influenced by a number of determinants (1, 2), and an abnormality of any one of them could be a factor contributing to the defective performance of the failing heart. Prominent among the determinants of myocar...
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Cytosolic Ca2+, [Ca]I , has a key role in intracellular signalling during excitation-contraction coupling (E-C coupling) in cardiac myocytes. The sarcoplasmic reticulum (SR) is a main intracellular Ca2+ store and the Na+-Ca2+ exchanger (NaCaX) is a major mechanism to extrude Ca2+ for balancing the Ca2+ influx via L-type Ca2+ channels during excitation. Furthermore, [Ca]I also affects the config...
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In order to assess the role played by endogenous norepinephrine (NE) stores in the intrinsic contractile state of cardiac muscle, the right ventricular papillary muscles from normal cats and cats with cardiac NE depletion produced by chronic cardiac denervation or reserpine pretreatment were studied. The contractile state of NE-depleted ventricular myocardium was found to be normal. The resting...
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AIMS To investigate whether strong cardiac sympathetic activity contributes primarily to sudden death or to worsening heart failure, and to determine the relationship of the size of cardiac noradrenaline stores to the mode of death. METHODS AND RESULTS The study population comprised 116 patients with congestive heart failure (ejection fraction 19+/-7%) and a mean follow-up of 18+/-19 months. ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1963
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1963.tb01494.x